The invention provides a liquid crystal display panel with a multi-domain pixel layout, including: a plurality of pixel units arranged in a matrix formed by columns and rows, wherein each pixel unit is divided into a plurality of domains; a first alignment layer aligned to directions along the columns; and a second alignment layer aligned to directions along the rows. For two adjacent pixel units arranged in the column direction, the domains adjacent to a boundary between the two adjacent pixel units are defined with the same directions which liquid crystal molecules tilt toward by the first and second alignment layers.