发明授权
US08911706B2 Complex of bifunctional chelating agent and mannosyl human serum albumin
有权
双功能螯合剂和甘露糖基人血清白蛋白的复合物
- 专利标题： Complex of bifunctional chelating agent and mannosyl human serum albumin
- 专利标题（中）： 双功能螯合剂和甘露糖基人血清白蛋白的复合物
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申请号： US13146280申请日： 2010-01-27
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公开(公告)号： US08911706B2公开(公告)日： 2014-12-16
- 发明人: Jae Min Jeong , Myung Chul Lee , June Key Chung , Dong Soo Lee
- 申请人： Jae Min Jeong , Myung Chul Lee , June Key Chung , Dong Soo Lee
- 申请人地址： KR
- 专利权人： SNU R&DB Foundation
- 当前专利权人： SNU R&DB Foundation
- 当前专利权人地址： KR
- 代理机构： Heslin Rothenberg Farley & Mesiti P.C.
- 优先权： KR10-2009-0006553 20090128
- 国际申请： PCT/KR2010/000488 WO 20100127
- 国际公布： WO2010/087612 WO 20100805
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61K36/14 ; A61K51/08 ; A61K51/04
摘要：
The present invention is about bifunctional chelating agents (BCA) conjugated mannosyl human serum albumin (MSA) and its radioisotope labeled compounds for imaging immune system such as macrophages, Kupffer cells, reticuloendothelial system (RES), and lymphatic system. The present invention comprises BCA-MSA conjugates, their radiolabeled compounds, and kits for radiolabeing. The present invention improved radiolabeling procedure, showed higher lymphatic system uptake, and enabled image by positron emission tomography (PET).
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