Highly power efficient transmitter output stage designs are provided. In an embodiment, the probability density function (PDF) of an input signal is divided into a plurality of regions, and samples of the input signal are processed depending on the region of the PDF within which they fall. The PDF can be divided between an inner region corresponding to samples of the input signal that are within a predetermined amplitude range, and outer regions corresponding to samples of the input signal that are outside of the predetermined amplitude range. Samples of the input signal that fall in the inner region are processed by a class A biased amplifier and samples of the input signal that fall in the outer regions are processed by a class B biased amplifier. Output stage designs according to embodiments can be implemented as power amplifiers or power digital-to-analog converters (DACs).