A system and method for multiple players to play an interactive game is disclosed herein. The system preferably includes monitoring device monitoring the vital signs of a user, a game console and a video monitor. The monitoring device is preferably an article having an optical sensor and accelerometer. The monitoring device preferably provides for the display of the following information about the user: pulse rate; blood oxygenation levels; calories expended by the user of a pre-set time period; target zones of activity; time; distance traveled; and/or dynamic blood pressure. The article is preferably a band worn on a user's wrist, arm or ankle.