发明授权
US08916690B2 Growth-inhibited hydroxyapatite, process for its preparation and use
有权
生长抑制羟基磷灰石,其制备和使用过程
- 专利标题: Growth-inhibited hydroxyapatite, process for its preparation and use
- 专利标题(中): 生长抑制羟基磷灰石,其制备和使用过程
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申请号: US13812497申请日: 2011-08-04
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公开(公告)号: US08916690B2公开(公告)日: 2014-12-23
- 发明人: Sascha Heinemann , Christiane Heinemann , Hartmut Worch , Thomas Hanke , Wolfgang Pompe
- 申请人: Sascha Heinemann , Christiane Heinemann , Hartmut Worch , Thomas Hanke , Wolfgang Pompe
- 申请人地址: DE Dresden
- 专利权人: Technische Universität Dresden
- 当前专利权人: Technische Universität Dresden
- 当前专利权人地址: DE Dresden
- 代理商 Gudrun E. Huckett
- 优先权: DE102010038926 20100804
- 国际申请: PCT/EP2011/063470 WO 20110804
- 国际公布: WO2012/017045 WO 20120209
- 主分类号: C08H1/00
- IPC分类号: C08H1/00 ; A61L27/44 ; A61L27/48 ; A61L27/12 ; C01B25/32 ; A61F2/28 ; A61L27/46 ; A61L27/24
摘要:
The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.
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