Methods and systems for content-aware mapping/error protection are disclosed. Aspects of one method may include controlling a MAC layer and/or a PHY layer (PHY/MAC layer), in a wireless communication device to wirelessly communicate multimedia information based on content of the multimedia information, which may comprise video information, audio information, and/or data. The controlling of the PHY/MAC layer may comprise selecting a forward error correction code and modulation to be applied to portions of the multimedia information, and selecting one or more antenna to transmit the portions of the multimedia information. The selection criteria may be based on priority assigned to the portions of the multimedia information, and on feedback information from the receiving device and/or a receiver co-located with the device transmitting the multimedia information.