Invention Grant
- Patent Title: Polymerases for nucleotide analogue incorporation
- Patent Title (中): 用于核苷酸类似物掺入的聚合酶
-
Application No.: US11645223Application Date: 2006-12-21
-
Publication No.: US08921086B2Publication Date: 2014-12-30
- Inventor: David K. Hanzel , Geoff Otto , Paul Peluso , Thang Pham , David R. Rank , Paul Mitsis , Fred Christians , Arek Bibillo , Insil Park , Sonya Clark , John Lyle
- Applicant: David K. Hanzel , Geoff Otto , Paul Peluso , Thang Pham , David R. Rank , Paul Mitsis , Fred Christians , Arek Bibillo , Insil Park , Sonya Clark , John Lyle
- Applicant Address: US CA Menlo Park
- Assignee: Pacific Biosciences of California, Inc.
- Current Assignee: Pacific Biosciences of California, Inc.
- Current Assignee Address: US CA Menlo Park
- Agency: Quine Intellectual Property Law Group, P.C.
- Agent Monicia Elrod-Erickson; Robert Reamey
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12P19/34 ; C12Q1/68
Abstract:
Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Public/Granted literature
- US20070196846A1 Polymerases for nucleotide analogue incorporation Public/Granted day:2007-08-23
Information query
