发明授权
- 专利标题： Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity
- 专利标题（中）： 介孔硅颗粒用于呈递肿瘤抗原和辅助抗癌免疫
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申请号： US13708888申请日： 2012-12-07
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公开(公告)号： US08926994B2公开(公告)日： 2015-01-06
- 发明人: Rita Elena Serda , Ismail Mustafa Meraz , Jianhua Gu , Xiaojun Xia , Haifa Shen , Tong Sun , Mauro Ferrari
- 申请人： The Methodist Hospital Research Institute
- 申请人地址： US TX Houston
- 专利权人： The Methodist Hospital Research Institute
- 当前专利权人： The Methodist Hospital Research Institute
- 当前专利权人地址： US TX Houston
- 代理机构： Haynes and Boone, LLP
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K47/48 ; A61K9/14
摘要：
Disclosed are mesoporous silicon multi-stage vehicles that comprise liposomal-based second-stage particles, as well as pharmaceutical compositions and formulations including such vectors for use in a variety of diagnostic and therapeutic indications. In particular embodiments, MSV comprising ligand decorated second-stage particles are provided for therapeutic methods including, for example, treatment of mammalian cancers, including those of the human breast.
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