发明授权
US08927692B2 Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same
有权
共识的前列腺抗原，编码相同的核酸分子和疫苗以及包含它们的用途
- 专利标题： Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same
- 专利标题（中）： 共识的前列腺抗原，编码相同的核酸分子和疫苗以及包含它们的用途
-
申请号： US13883978申请日： 2011-11-14
-
公开(公告)号： US08927692B2公开(公告)日： 2015-01-06
- 发明人: David B Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y Sardesai , Mathura P Ramanathan
- 申请人： David B Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y Sardesai , Mathura P Ramanathan
- 申请人地址： US PA Philadelphia US PA Plymouth Meeting
- 专利权人： The Trustees of the University of Pennsylvania,Inovio Pharmaceuticals, Inc.
- 当前专利权人： The Trustees of the University of Pennsylvania,Inovio Pharmaceuticals, Inc.
- 当前专利权人地址： US PA Philadelphia US PA Plymouth Meeting
- 代理机构： Riverside Law LLP
- 国际申请： PCT/US2011/060592 WO 20111114
- 国际公布： WO2012/065164 WO 20120518
- 主分类号： C07K7/00
- IPC分类号： C07K7/00 ; A61K39/00
摘要：
Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
公开/授权文献
信息查询
