Invention Grant
- Patent Title: 2-arylimidazole derivatives as PDE10A enzyme inhibitors
- Patent Title (中): 2-芳基咪唑衍生物作为PDE10A酶抑制剂
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Application No.: US13924712Application Date: 2013-06-24
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Publication No.: US08927738B2Publication Date: 2015-01-06
- Inventor: Ask Puschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morton Langgard
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agent Mary Catherine Di Nunzio
- Priority: DK200901341 20091217
- Main IPC: C07D233/64
- IPC: C07D233/64 ; C07D487/04 ; C07D471/04

Abstract:
This invention is directed to compounds of formula I having the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
Public/Granted literature
- US20130289038A1 2-ARYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS Public/Granted day:2013-10-31
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