发明授权
US08927755B2 I- and II-type crystals of L-alpha-glyceryl phosphoryl choline, and method for preparing same
有权
L-α-甘油磷酰胆碱的I型和II型晶体及其制备方法
- 专利标题： I- and II-type crystals of L-alpha-glyceryl phosphoryl choline, and method for preparing same
- 专利标题（中）： L-α-甘油磷酰胆碱的I型和II型晶体及其制备方法
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申请号： US14003276申请日： 2012-02-22
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公开(公告)号： US08927755B2公开(公告)日： 2015-01-06
- 发明人: Min-Keun Oh , Ki-Nam Kim , Ki-Hyeong Seo , Dae-Gil Kwon
- 申请人： Min-Keun Oh , Ki-Nam Kim , Ki-Hyeong Seo , Dae-Gil Kwon
- 申请人地址： KR Pyeongtaek-Si
- 专利权人： Hanseochem Co., Ltd.
- 当前专利权人： Hanseochem Co., Ltd.
- 当前专利权人地址： KR Pyeongtaek-Si
- 代理机构： Lexyoume IP Meister, PLLC
- 优先权： KR10-2011-0022392 20110314; KR10-2011-0022393 20110314
- 国际申请： PCT/KR2012/001331 WO 20120222
- 国际公布： WO2012/124907 WO 20120920
- 主分类号： C07F9/09
- IPC分类号： C07F9/09
摘要：
The present invention relates to I- and II-type crystals of L-α-glyceryl phosphoryl choline, and to a method for preparing same. More particularly, the present invention relates to noble I- and II-type anhydride crystals of L-α-glyceryl phosphoryl choline, which have a higher purity than conventional liquid L-α-glyceryl phosphoryl choline, and one advantage of which is that formulations and dosages of pharmaceuticals are easily modified, and another advantage of which is that the hygroscopicity of the crystals are much lower than that of conventional polymorphic crystals, providing excellent stability during storage. The present invention also relates to a method for preparing the I- and II-type crystals of L-α-glyceryl phosphoryl choline.