Invention Grant
- Patent Title: Method of treating a disease or condition characterised by aberrant epithelial cell proliferation
- Patent Title (中): 治疗以异常上皮细胞增殖为特征的疾病或病症的方法
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Application No.: US14032848Application Date: 2013-09-20
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Publication No.: US08933027B2Publication Date: 2015-01-13
- Inventor: Zee Upton , Jennifer Ann Kricker
- Applicant: Queensland University of Technology
- Applicant Address: AU Brisbane, Queensland
- Assignee: Queensland University of Technology
- Current Assignee: Queensland University of Technology
- Current Assignee Address: AU Brisbane, Queensland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- Priority: AUPR0309 20000922
- Main IPC: A61K38/30
- IPC: A61K38/30 ; A61K38/39 ; A61P35/00 ; C07K14/65 ; A61K47/48 ; A61K38/17 ; C07K14/71 ; C07K14/78
Abstract:
A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an agent which disrupts an isolated protein complex including: insulin-like growth factor I (IGF-I); an insulin-like growth factor binding protein (IGFBP) selected from IGFBP-3 and IGFBP-5; and vitronectin; or which prevents formation of the isolated protein complex, to thereby treat the disease or condition in the mammal. The agent is selected from the group consisting a polypeptide that is distinguished from IGF-II by substitution of at least one amino acid residue, wherein the polypeptide disrupts the isolated protein complex.
Public/Granted literature
- US20140045749A1 GROWTH FACTOR COMPLEX Public/Granted day:2014-02-13
Information query
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