发明授权
- 专利标题： Methods for regulation of p53 translation and function
- 专利标题（中）： 调节p53翻译和功能的方法
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申请号： US12063463申请日： 2006-09-28
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公开(公告)号： US08933043B2公开(公告)日： 2015-01-13
- 发明人: Masatoshi Takagi , Michael B. Kastan
- 申请人： Masatoshi Takagi , Michael B. Kastan
- 申请人地址： US TN Memphis
- 专利权人： St. Jude Children's Research Hospital
- 当前专利权人： St. Jude Children's Research Hospital
- 当前专利权人地址： US TN Memphis
- 代理机构： Troutman Sanders LLP
- 国际申请： PCT/US2006/037848 WO 20060928
- 国际公布： WO2007/041213 WO 20070412
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; A61K48/00 ; C12N15/113
摘要：
The present invention relates to novel methods for modulating the activity of p53 tumor suppressor protein by affecting p53 translational regulation. More specifically, the invention relates to novel methods for modulating p53 mRNA translation in a cell by affecting a function of a p53 5′-untranslated region (5′UTR), including its interaction with proteins such as Ribosomal Protein L26 (RPL26), nucleolin, and p53. The invention also relates to the use of these methods for treating cancer, neurodegenerative disorders and minimizing the negative effects of cellular stresses.
公开/授权文献
- US20090149377A1 METHODS FOR REGULATION OF p53 TRANSLATION AND FUNCTION 公开/授权日：2009-06-11
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