发明授权
US08933101B2 Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
有权
Thia(dia)zoles作为快速解离的多巴胺2受体拮抗剂
- 专利标题: Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
- 专利标题(中): Thia(dia)zoles作为快速解离的多巴胺2受体拮抗剂
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申请号: US12597164申请日: 2008-04-18
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公开(公告)号: US08933101B2公开(公告)日: 2015-01-13
- 发明人: Gregor James MacDonald , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
- 申请人: Gregor James MacDonald , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
- 申请人地址: BE Beerse
- 专利权人: Janssen Pharmaceutica NV
- 当前专利权人: Janssen Pharmaceutica NV
- 当前专利权人地址: BE Beerse
- 代理商 Hal B. Woodrow
- 优先权: EP07106706 20070423
- 国际申请: PCT/EP2008/054732 WO 20080418
- 国际公布: WO2008/128996 WO 20081030
- 主分类号: A61K31/454
- IPC分类号: A61K31/454 ; C07D417/12 ; C07D401/12
摘要:
The present invention relates to [1-(benzyl)-piperidin-4-yl]-([1,3,4]thiadiazol-2-yl)-amine and [1-(benzyl)-piperidin-4-yl]-(thiazol-2-yl)-amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
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