A multi-leaf collimator for a radiotherapy apparatus comprises at least one array of laterally-spaced elongate leaves, each leaf being driven by an associated motor connected to the leaf via a drive means so as to extend or retract the leaf in its longitudinal direction, the drive means comprising a sub-frame on which at least a subset of the motors are mounted, the sub-frame being mounted at a location spaced from the leaf array in a direction transverse to the lateral and longitudinal directions, and including a plurality of threaded drives disposed longitudinally, each being driven by a motor and being operatively connected to a leaf thereby to drive that leaf.