Techniques for isochronous data transfer between different memory-mapped domains in a distributed system. A method includes configuring an isochronous engine with an isochronous period. The method further includes transferring data over a memory-mapped fabric from a first memory to a second memory during a specified portion of a cycle of the isochronous period. The first memory is comprised in a first device in a first memory-mapped domain of the memory-mapped fabric and the second memory is comprised in a second device in a second memory-mapped domain of the memory-mapped fabric. The method may further comprise translating one or more addresses related to the transferring. The memory-mapped fabric may be a PCI-Express fabric. The transferring may be performed by a DMA controller. A non-transparent bridge may separate the first and the second memory-mapped domains and may perform the translating.