发明授权
US08946172B2 Method for reducing scarring during wound healing using antisense compounds directed to CTGF
有权
使用针对CTGF的反义化合物在伤口愈合过程中减少瘢痕形成的方法
- 专利标题: Method for reducing scarring during wound healing using antisense compounds directed to CTGF
- 专利标题(中): 使用针对CTGF的反义化合物在伤口愈合过程中减少瘢痕形成的方法
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申请号: US12547481申请日: 2009-08-26
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公开(公告)号: US08946172B2公开(公告)日: 2015-02-03
- 发明人: Thomas A. Mustoe , Nicholas M. Dean , Mark Sisco , Zol Kryger , C. Frank Bennett
- 申请人: Thomas A. Mustoe , Nicholas M. Dean , Mark Sisco , Zol Kryger , C. Frank Bennett
- 申请人地址: US NY New York US CA Carlsbad US IL Evanston
- 专利权人: Excaliard Pharmaceuticals, Inc.,Isis Pharmaceuticals, Inc.,Northwestern University
- 当前专利权人: Excaliard Pharmaceuticals, Inc.,Isis Pharmaceuticals, Inc.,Northwestern University
- 当前专利权人地址: US NY New York US CA Carlsbad US IL Evanston
- 代理机构: Lando & Anastasi LLP
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; C07H21/04
摘要:
This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.
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