发明授权
- 专利标题： Fused aminodihydrothiazine derivatives
- 专利标题（中）： 融合氨基二氢噻嗪衍生物
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申请号： US13333238申请日： 2011-12-21
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公开(公告)号： US08946210B2公开(公告)日： 2015-02-03
- 发明人: Yuichi Suzuki , Takafumi Motoki , Toshihiko Kaneko , Mamoru Takaishi , Tasuku Ishida , Yoichi Kita , Kunitoshi Takeda , Noboru Yamamoto , Afzal Khan , Paschalis Dimopoulos
- 申请人： Yuichi Suzuki , Takafumi Motoki , Toshihiko Kaneko , Mamoru Takaishi , Tasuku Ishida , Yoichi Kita , Kunitoshi Takeda , Noboru Yamamoto , Afzal Khan , Paschalis Dimopoulos
- 申请人地址： JP Tokyo
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Fish & Richardson P.C.
- 优先权： JP2008-008680 20080118; JP2008-197204 20080731
- 主分类号： C07D239/14
- IPC分类号： C07D239/14 ; A61K31/5415
摘要：
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
公开/授权文献
- US20120094984A1 FUSED AMINODIHYDROTHIAZINE DERIVATIVES 公开/授权日：2012-04-19