Invention Grant
US08946296B2 Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
有权
取代的杂芳基 - 和芳基 - 环丙胺乙酰胺及其用途
- Patent Title: Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
- Patent Title (中): 取代的杂芳基 - 和芳基 - 环丙胺乙酰胺及其用途
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Application No.: US13500687Application Date: 2010-04-19
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Publication No.: US08946296B2Publication Date: 2015-02-03
- Inventor: Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
- Applicant: Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Matthew Colin Thor Fyfe
- Applicant Address: ES Barcelona
- Assignee: Oryzon Genomics S.A.
- Current Assignee: Oryzon Genomics S.A.
- Current Assignee Address: ES Barcelona
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP09172705 20091009
- International Application: PCT/EP2010/055103 WO 20100419
- International Announcement: WO2011/042217 WO 20110414
- Main IPC: A61K31/165
- IPC: A61K31/165 ; C07C237/20 ; C07C237/06 ; C07C255/54 ; C07D213/36

Abstract:
The invention relates to compounds of Formula (I): (A′)x-(A)-(B)—(Z)-(L)-C(═O)NH2 or pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A′), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; and (L) is —(CH2)mCR1,R2—, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein R1 and R2 are each independently hydrogen or C1-C6 alkyl; provided that, if (L) is —CH2— or —CH(CH3)—, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases.
Public/Granted literature
- US20120264823A1 SUBSTITUTED HETEROARYL- AND ARYL-CYCLOPROPYLAMINE ACETAMIDES AND THEIR USE Public/Granted day:2012-10-18
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