Disclosed is a frame transmission method using precoding for supporting MU-MIMO, which facilitates to reduce overhead of a downlink frame in a wireless communication system of FDD method, and a base station supporting that method. The frame transmission method comprises calculating a precoding matrix of a present frame based on channel state information (CSI) of each mobile station and a precoding matrix of a prior frame; precoding a dedicated pilot and downlink data to be transmitted to the mobile station by the use of precoding matrix of the present frame; and transmitting a downlink frame including the precoded dedicated pilot and precoded downlink data to the corresponding mobile station.