Invention Grant
- Patent Title: Inhibitors of the renal outer medullary potassium channel
- Patent Title (中): 肾外髓质钾通道抑制剂
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Application No.: US13951096Application Date: 2013-07-25
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Publication No.: US08952166B2Publication Date: 2015-02-10
- Inventor: Fa-Xiang Ding , Shuzhi Dong , Jessica Frie , Xin Gu , Jinlong Jiang , Alexander Pasternak , Haifeng Tang , Zhicai Wu , Yang Yu , Takao Suzuki
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Catherine D. Fitch; Nicole M. Beeler
- Priority: WOPCT/CN12/79184 20120726
- Main IPC: C07D471/10
- IPC: C07D471/10 ; C07D307/88 ; C07D498/20 ; C07D519/00 ; C07D471/20 ; A61K31/438 ; A61K31/46 ; A61K31/435 ; A61K31/4995 ; A61K31/5386 ; A61K45/06 ; C07D451/00
Abstract:
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
Public/Granted literature
- US20140031349A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Public/Granted day:2014-01-30
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