A low voltage differential signal driving circuit including positive and negative differential output terminals, an automatic level selector, an output level detector and a transition accelerator. The positive and negative differential output terminals provide a transmission interface with a differential output signal for transmission of a data signal. The automatic level selector outputs a reference voltage corresponding to the transmission interface. The output level detector generates a low-high (or high-low) transition acceleration control signal based on the data signal, the reference voltage, and VTXP signal at the positive differential output terminal (or VTXN signal at the negative differential output terminal). In accordance with the low-high (or high-low) transition acceleration control signal, the transition accelerator couples the positive (or negative) differential output terminal to a high voltage source and couples the negative (or positive) differential output terminal to a low voltage source to accelerate transition of the differential output signal.