Response frame modulation coding set (MCS) selection within single user, multiple user, multiple access, and/or MIMO wireless communications. With respect to any exchange between communication devices in which there is a response frame, a first frame (e.g., an eliciting frame) is a first transmitted from the eliciting communication device to the responding communication device, and a second frame (e.g., a response frame) is transmitted from the responding communication device to the eliciting communities device. Appropriate selection of MCS to be used within the response frame may be determined explicitly or implicitly. One or more parameters (e.g., a limit parameter, a reduction parameter, etc.) may be used to determine the MCS of the response frame. The MCS employed for a response frame may be selected from a basic MCS set that ensures all response frames from any responding communication device may be properly received by the eliciting communication device.