Invention Grant
US08962315B2 Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen
有权
包含重组B淋巴细胞细胞系的组合物和方法，包括至少一种表达至少一种能够与第一抗原反应的内源性膜免疫球蛋白的内源基因，并包括至少一种外源掺入的表达至少一种与第二抗原反应的外源性分泌的免疫球蛋白
- Patent Title: Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen
- Patent Title (中): 包含重组B淋巴细胞细胞系的组合物和方法，包括至少一种表达至少一种能够与第一抗原反应的内源性膜免疫球蛋白的内源基因，并包括至少一种外源掺入的表达至少一种与第二抗原反应的外源性分泌的免疫球蛋白
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Application No.: US13374353Application Date: 2011-12-22
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Publication No.: US08962315B2Publication Date: 2015-02-24
- Inventor: Roderick A. Hyde , Wayne R. Kindsvogel
- Applicant: Roderick A. Hyde , Wayne R. Kindsvogel
- Applicant Address: US WA Bellevue
- Assignee: Elwha LLC
- Current Assignee: Elwha LLC
- Current Assignee Address: US WA Bellevue
- Main IPC: C12N5/06
- IPC: C12N5/06 ; C12N15/63
Abstract:
Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated recombinant cell line includes an isolated B lymphocyte cell line capable of expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and at least one exogenously incorporated nucleic acid encoding at least one secreted immunoglobulin reactive to a second antigen.
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