发明授权
US08962341B2 Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis
有权
通过与CKAP4的相互作用进行基于细胞的APF检测来诊断间质性膀胱炎
- 专利标题： Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis
- 专利标题（中）： 通过与CKAP4的相互作用进行基于细胞的APF检测来诊断间质性膀胱炎
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申请号： US13133244申请日： 2009-12-10
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公开(公告)号： US08962341B2公开(公告)日： 2015-02-24
- 发明人: David Alan Zacharias , Sonia Lobo Planey
- 申请人： David Alan Zacharias , Sonia Lobo Planey
- 申请人地址： US PA Scranton US FL Gainesville
- 专利权人： The Commonwealth Medical College,University of Florida Research Foundation, Inc.
- 当前专利权人： The Commonwealth Medical College,University of Florida Research Foundation, Inc.
- 当前专利权人地址： US PA Scranton US FL Gainesville
- 代理机构： Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
- 国际申请： PCT/US2009/067487 WO 20091210
- 国际公布： WO2010/068747 WO 20100617
- 主分类号： G01N21/77
- IPC分类号： G01N21/77 ; C12M3/00 ; G01N21/75 ; G01N33/50 ; C07K9/00 ; C07K14/705 ; C12Q1/68 ; G01N33/68
摘要：
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
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