Invention Grant
- Patent Title: Amorphous asiatic tromethamine salt and preparation method thereof
- Patent Title (中): 无定形亚洲氨丁三醇盐及其制备方法
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Application No.: US14006198Application Date: 2012-03-21
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Publication No.: US08962880B2Publication Date: 2015-02-24
- Inventor: Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
- Applicant: Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
- Applicant Address: CN Shanghai
- Assignee: Shanghai Institute of Pharmaceutical Industry
- Current Assignee: Shanghai Institute of Pharmaceutical Industry
- Current Assignee Address: CN Shanghai
- Agency: Oliff PLC
- Priority: CN201110069862 20110322
- International Application: PCT/CN2012/072690 WO 20120321
- International Announcement: WO2012/126363 WO 20120927
- Main IPC: C07C227/14
- IPC: C07C227/14 ; C07C215/10 ; C07C229/38 ; C07J63/00
Abstract:
An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.
Public/Granted literature
- US20140243553A1 AMORPHOUS ASIATIC TROMETHAMINE SALT AND PREPARATION METHOD THEREOF Public/Granted day:2014-08-28
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