Invention Grant
US08968740B2 Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1
有权
使用半乳凝素-1的移植后淋巴增殖性疾病和缺氧相关血管生成障碍的诊断，预后，监测，治疗和调节的组合物，试剂盒和方法
- Patent Title: Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1
- Patent Title (中): 使用半乳凝素-1的移植后淋巴增殖性疾病和缺氧相关血管生成障碍的诊断，预后，监测，治疗和调节的组合物，试剂盒和方法
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Application No.: US13509466Application Date: 2010-11-12
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Publication No.: US08968740B2Publication Date: 2015-03-03
- Inventor: Margaret A. Shipp , Jing Ouyang , Kunihiko Takeyama , Jeffery L. Kutok , Scott J. Rodig , Gabriel Rabinovich , Diego Omar Croci Russo , Mariana Salatino
- Applicant: Margaret A. Shipp , Jing Ouyang , Kunihiko Takeyama , Jeffery L. Kutok , Scott J. Rodig , Gabriel Rabinovich , Diego Omar Croci Russo , Mariana Salatino
- Applicant Address: US MA Boston US MA Boston AR Buenos Aires AR Buenos Aires
- Assignee: Dana-Farber Cancer Institute, Inc.,The Brigham and Women's Hospital, Inc.,Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET),Fundacion Sales
- Current Assignee: Dana-Farber Cancer Institute, Inc.,The Brigham and Women's Hospital, Inc.,Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET),Fundacion Sales
- Current Assignee Address: US MA Boston US MA Boston AR Buenos Aires AR Buenos Aires
- Agency: Foley Hoag LLP
- International Application: PCT/US2010/056547 WO 20101112
- International Announcement: WO2011/060272 WO 20110519
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12N5/20 ; C07K16/18 ; C07K16/22 ; A61K39/00
Abstract:
The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and methods for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.
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