发明授权
- 专利标题: Methods and compounds for preventing and treating a tumour
- 专利标题(中): 用于预防和治疗肿瘤的方法和化合物
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申请号: US12740912申请日: 2008-11-03
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公开(公告)号: US08969313B2公开(公告)日: 2015-03-03
- 发明人: Qiang Yu
- 申请人: Qiang Yu
- 申请人地址: SG Singapore
- 专利权人: Agency for Science, Technology and Research
- 当前专利权人: Agency for Science, Technology and Research
- 当前专利权人地址: SG Singapore
- 代理机构: Blakely, Sokoloff, Taylor & Zafman LLP
- 国际申请: PCT/SG2008/000420 WO 20081103
- 国际公布: WO2009/058102 WO 20090507
- 主分类号: A61K31/7064
- IPC分类号: A61K31/7064 ; A61P35/00 ; G01N33/53 ; A61K31/519 ; A61K31/52 ; G01N33/50
摘要:
The invention relates to a method of preventing, inhibiting, arresting or reversing tumorigenesis in a cell as well as a method of inducing apoptosis in a tumor cell. The method includes increasing the amount and/or the activity of a DACT protein, or a functional fragment thereof, in the cell. Also provided is a pharmaceutical composition that comprises a compound of general formula (I), wherein A is CH or N, R1, R4 and R5 are independent from each other H, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group comprising 0-3 heteroatoms. The heteroatoms may be N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen such as F, Cl, Br or L. R3 is H, F, Cl or an aliphatic or arylaliphatic group that includes 1-8 main chain carbon atoms and 0-3 heteroatoms. The pharmaceutical composition also comprises a histone deacetylase inhibitor.