发明授权
- 专利标题： Ether benzotriazole derivatives
- 专利标题（中）： 醚苯并三唑衍生物
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申请号： US13391315申请日： 2010-08-16
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公开(公告)号： US08975286B2公开(公告)日： 2015-03-10
- 发明人: Vadim Y. Dudkin , Mark E. Fraley , Cheng Wang , Robert M. Garbaccio , Douglas C. Beshore , Scott K. Kuduk , Jason W. Skudlarek
- 申请人： Vadim Y. Dudkin , Mark E. Fraley , Cheng Wang , Robert M. Garbaccio , Douglas C. Beshore , Scott K. Kuduk , Jason W. Skudlarek
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Keith D. MacMillan; John C. Todaro
- 国际申请： PCT/US2010/045566 WO 20100816
- 国际公布： WO2011/022312 WO 20110224
- 主分类号： C07D409/14
- IPC分类号： C07D409/14 ; C07D405/14 ; C07D401/14 ; C07D401/12 ; C07D403/12 ; C07D249/18 ; A61K31/506 ; A61K31/497 ; A61K31/496 ; A61K31/454 ; A61K31/4545 ; A61K31/444 ; A61K31/4439 ; A61K31/4192 ; C07D417/14 ; C07D403/14 ; C07D413/14 ; C07D417/12 ; C07D471/04 ; C07D471/08 ; C07D471/10 ; C07D487/04 ; C07D487/08 ; C07D487/10 ; C07D495/04
摘要：
The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
公开/授权文献
- US20120149677A1 ETHER BENZOTRIAZOLE DERIVATIVES 公开/授权日：2012-06-14