发明授权
- 专利标题： Polymerized cyclic nitroxide radical compound and use thereof
- 专利标题（中）： 聚合环氧氮自由基化合物及其用途
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申请号： US12990575申请日： 2008-12-04
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公开(公告)号： US08980241B2公开(公告)日： 2015-03-17
- 发明人: Yukio Nagasaki , Toru Yoshitomi , Hirofumi Matsui , Aki Hirayama , Takashi Mamiya , Akira Matsumura , Kensuke Suzuki , Hideo Tsurushima , Aiki Marushima , Kazuko Toh , Daisuke Miyamoto
- 申请人： Yukio Nagasaki , Toru Yoshitomi , Hirofumi Matsui , Aki Hirayama , Takashi Mamiya , Akira Matsumura , Kensuke Suzuki , Hideo Tsurushima , Aiki Marushima , Kazuko Toh , Daisuke Miyamoto
- 申请人地址： JP Ibaraki
- 专利权人： University of Tsukuba
- 当前专利权人： University of Tsukuba
- 当前专利权人地址： JP Ibaraki
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 优先权： JP2008-120626 20080502; JP2008-178150 20080708
- 国际申请： PCT/JP2008/072467 WO 20081204
- 国际公布： WO2009/133647 WO 20091105
- 主分类号： A61K31/74
- IPC分类号： A61K31/74 ; C08F8/30 ; A23L1/30 ; A61K47/48 ; A61K49/08 ; A61K49/12 ; A61K49/18 ; A61K49/20 ; B82Y5/00 ; C08G65/333 ; C08G65/334 ; C08G73/10 ; C08L71/02 ; C08L23/00 ; C08L25/00 ; C08L71/03 ; C08L79/00
摘要：
A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.