发明授权
US08987468B2 Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
有权
化合物,药物组合物和异羟肟酸衍生物的使用方法
- 专利标题: Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
- 专利标题(中): 化合物,药物组合物和异羟肟酸衍生物的使用方法
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申请号: US12865903申请日: 2009-02-03
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公开(公告)号: US08987468B2公开(公告)日: 2015-03-24
- 发明人: Tong Wang , Stephen Gately
- 申请人: Tong Wang , Stephen Gately
- 申请人地址: US AZ Phoenix
- 专利权人: The Translational Genomics Research Institute
- 当前专利权人: The Translational Genomics Research Institute
- 当前专利权人地址: US AZ Phoenix
- 国际申请: PCT/US2009/032917 WO 20090203
- 国际公布: WO2009/100045 WO 20090813
- 主分类号: C07D235/00
- IPC分类号: C07D235/00 ; C07C239/00 ; C07C259/00 ; C07D235/16 ; C07D403/04
摘要:
The invention encompasses a compound derived from hydroxamic acid that may be used to slow the expansion of cancer cells and thus is effective in the treatment of cancer. Generally, the disclosed compound includes a benzimidazole group coupled to a hydroxyamide of five or more unsubstituted carbon atoms and any pharmaceutically acceptable salts, solvates and chemically protected forms thereof. Also disclosed are pharmacological compositions including the compound and methods of using the compound to slow the expansion of cancer cells as well as methods of using the compound to treat cancer.
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