发明授权
- 专利标题: Process for the preparation of pyrazole-4-carboxamides
- 专利标题(中): 制备吡唑-4-甲酰胺的方法
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申请号: US13881366申请日: 2011-10-25
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公开(公告)号: US08987470B2公开(公告)日: 2015-03-24
- 发明人: Max Josef Braun
- 申请人: Max Josef Braun
- 申请人地址: BE Brussels
- 专利权人: Solvay SA
- 当前专利权人: Solvay SA
- 当前专利权人地址: BE Brussels
- 国际申请: PCT/EP2011/068653 WO 20111025
- 国际公布: WO2012/055864 WO 20120503
- 主分类号: C07D231/14
- IPC分类号: C07D231/14
摘要:
A process for the manufacture of pyrazole-4-carboxamides, in particular, of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamides which are useful as pharmaceuticals and agrochemicals. The carboxamides are prepared from the corresponding pyzole-4-carboxylic acid esters and appropriate amine in the presence of a base. The reaction is performed in a reaction medium which is essentially free of water; alternatively, the base is used in an amount equal to or greater than 0.25 equivalents per mole of amine.
公开/授权文献
- US20130225833A1 Process for the preparation of pyrazole-4-carboxamides 公开/授权日:2013-08-29
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