发明授权
US08987470B2 Process for the preparation of pyrazole-4-carboxamides 有权
制备吡唑-4-甲酰胺的方法

  • 专利标题: Process for the preparation of pyrazole-4-carboxamides
  • 专利标题(中): 制备吡唑-4-甲酰胺的方法
  • 申请号: US13881366
    申请日: 2011-10-25
  • 公开(公告)号: US08987470B2
    公开(公告)日: 2015-03-24
  • 发明人: Max Josef Braun
  • 申请人: Max Josef Braun
  • 申请人地址: BE Brussels
  • 专利权人: Solvay SA
  • 当前专利权人: Solvay SA
  • 当前专利权人地址: BE Brussels
  • 国际申请: PCT/EP2011/068653 WO 20111025
  • 国际公布: WO2012/055864 WO 20120503
  • 主分类号: C07D231/14
  • IPC分类号: C07D231/14
Process for the preparation of pyrazole-4-carboxamides
摘要:
A process for the manufacture of pyrazole-4-carboxamides, in particular, of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamides which are useful as pharmaceuticals and agrochemicals. The carboxamides are prepared from the corresponding pyzole-4-carboxylic acid esters and appropriate amine in the presence of a base. The reaction is performed in a reaction medium which is essentially free of water; alternatively, the base is used in an amount equal to or greater than 0.25 equivalents per mole of amine.
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