The subject matter described herein includes systems, methods, and computer readable media for utilizing quota usage policy control in a Diameter-based communication network. An exemplary method includes, at a policy server, sending a request for quota usage information associated with a subscriber to an online charging system (OCS) node. The method further includes receiving the quota usage information from the OCS node, generating at least one policy and charging control (PCC) rule for modifying a quality of service (QoS) policy attribute associated with the subscriber based on the quota usage information, and communicating the at least one PCC rule to a Diameter network element.