A medical system may include a control module and a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient. The control module may be configured to control the therapy delivery module to deliver electrical stimulation at a first stimulation intensity for a first time period, to deliver electrical stimulation at a second stimulation intensity for a second time period immediately following the first time period, and to deliver electrical stimulation at the first stimulation intensity for a third time period immediately following the second time period. The second stimulation intensity may be less than the first stimulation intensity. The electrical stimulation may elicit a first inhibitory physiological response during the first time period and a second inhibitory physiological response during the second time period. The second inhibitory physiological response may be greater than the first inhibitory physiological response.