发明授权
- 专利标题： Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
- 专利标题（中）： 低吸湿性阿立哌唑药物及其制备方法
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申请号： US13749753申请日： 2013-01-25
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公开(公告)号： US08993761B2公开(公告)日： 2015-03-31
- 发明人: Takuji Bando , Satoshi Aoki , Junichi Kawasaki , Makoto Ishigami , Youichi Taniguchi , Tsuyoshi Yabuuchi , Kiyoshi Fujimoto , Yoshihiro Nishioka , Noriyuki Kobayashi , Tsutomu Fujimura , Masanori Takahashi , Kaoru Abe , Tomonori Nakagawa , Koichi Shinhama , Naoto Utsumi , Michiaki Tominaga , Yoshihiro Ooi , Shohei Yamada , Kenji Tomikawa
- 申请人： Otsuka Pharmaceutical Co. Ltd.
- 申请人地址： JP Tokyo
- 专利权人： Otsuka Pharamceutical Co. Ltd.
- 当前专利权人： Otsuka Pharamceutical Co. Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- 优先权： JP2001-290645 20010925; JP2001-348276 20011114; CA2379005 20020327
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D215/227
摘要：
The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.
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