Invention Grant
- Patent Title: Variant activin receptor polypeptides and uses thereof
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Application No.: US13932421Application Date: 2013-07-01
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Publication No.: US08999917B2Publication Date: 2015-04-07
- Inventor: Jeonghoon Sun , Lei-Ting Tony Tam , Huiquan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou , John Lu
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Fenwick & West LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P35/00 ; C07K14/705 ; C07K14/71 ; A61K38/45 ; A61K31/513 ; A61K31/655 ; A61K38/17 ; A61K38/19 ; A61K38/20 ; A61K38/21 ; A61K38/50
Abstract:
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Public/Granted literature
- US20130288983A1 VARIANT ACTIVIN RECEPTOR POLYPEPTIDES AND USES THEREOF Public/Granted day:2013-10-31
Information query
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