Invention Grant
- Patent Title: Process for the preparation of anhydrous aripiprazole crystal form II
- Patent Title (中): 制备无水阿立哌唑晶体的方法II
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Application No.: US14008167Application Date: 2012-03-30
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Publication No.: US09000165B2Publication Date: 2015-04-07
- Inventor: Soo Jin Choi , Seong Soo Oh , Yong Suk Jin , Yong Tae Kim , Seung Jae Lee , Jeong Hyun Son
- Applicant: Soo Jin Choi , Seong Soo Oh , Yong Suk Jin , Yong Tae Kim , Seung Jae Lee , Jeong Hyun Son
- Applicant Address: KR Seongnam-si
- Assignee: Daewoong Pharmaceutical Co., Ltd.
- Current Assignee: Daewoong Pharmaceutical Co., Ltd.
- Current Assignee Address: KR Seongnam-si
- Agency: Seed IP Law Group PLLC
- Priority: KR10-2011-0029931 20110331
- International Application: PCT/KR2012/002349 WO 20120330
- International Announcement: WO2012/134206 WO 20121004
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D215/227 ; A61K31/4709 ; A61K31/496
Abstract:
The present invention relates to a process for preparation of aripiprazole crystal form II by recrystallizing aripiprazole in a mixture of acetone and 1-methoxy-2-propanol or a single solvent of 1-methoxy-2-propanol. The simple process according to the present invention can produce aripiprazole crystal form II with high purity and high yield in a mass scale.
Public/Granted literature
- US20140114071A1 PROCESS FOR THE PREPARATION OF ANHYDROUS ARIPIPRAZOLE CRYSTAL FORM II Public/Granted day:2014-04-24
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