Invention Grant
US09011856B2 Antibodies specific for sclerostin and methods for increasing bone mineralization
有权
针对硬皮蛋白的特异性抗体和增加骨矿化的方法
- Patent Title: Antibodies specific for sclerostin and methods for increasing bone mineralization
- Patent Title (中): 针对硬皮蛋白的特异性抗体和增加骨矿化的方法
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Application No.: US13670259Application Date: 2012-11-06
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Publication No.: US09011856B2Publication Date: 2015-04-21
- Inventor: David G. Winkler , Jiye Shi , John Latham
- Applicant: UCB Pharma S.A.
- Applicant Address: BE Brussels
- Assignee: UCB Pharma S.A.
- Current Assignee: UCB Pharma S.A.
- Current Assignee Address: BE Brussels
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; G01N33/53 ; C07K16/22 ; C07K14/51
Abstract:
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
Public/Granted literature
- US20130064830A1 Antibodies Specific for Sclerostin and Methods for Increasing Bone Mineralization Public/Granted day:2013-03-14
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