发明授权
US09012451B2 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists
有权
氮杂双环烷基醚及其用作ALPHA7-nachr激动剂
- 专利标题： Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists
- 专利标题（中）： 氮杂双环烷基醚及其用作ALPHA7-nachr激动剂
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申请号： US13462187申请日： 2012-05-02
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公开(公告)号： US09012451B2公开(公告)日： 2015-04-21
- 发明人: Dominik Feuerbach , Konstanze Hurth , Timothy John Ritchie
- 申请人： Dominik Feuerbach , Konstanze Hurth , Timothy John Ritchie
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理机构： Strain & Strain PLLC
- 代理商 Paul D. Strain, Esq.
- 优先权： GB220581.3 20020904
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61K31/501 ; A61K31/505 ; A61K31/506 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D409/14 ; C07D487/08 ; C07D453/02 ; A61P25/18 ; A61P25/08 ; A61P25/16 ; A61P33/06 ; A61P25/02 ; A61P25/28
摘要：
The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
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