发明授权
- 专利标题： Biodegradable lipids for the delivery of active agents
- 专利标题（中）： 用于递送活性剂的生物可降解脂质
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申请号： US13153200申请日： 2011-06-03
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公开(公告)号： US09012498B2公开(公告)日： 2015-04-21
- 发明人: Muthiah Manoharan , Martin Maier , Muthusamy Jayaraman , Shigeo Matsuda , Narayanannair K. Jayaprakash , Kallanthottathil G. Rajeev , Akin Akinc , Thomas A. Baillie
- 申请人： Muthiah Manoharan , Martin Maier , Muthusamy Jayaraman , Shigeo Matsuda , Narayanannair K. Jayaprakash , Kallanthottathil G. Rajeev , Akin Akinc , Thomas A. Baillie
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Blank Rome LLP
- 主分类号： A61K31/265
- IPC分类号： A61K31/265 ; A61K31/13 ; C07C229/00 ; C07C229/12 ; C12N15/88
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
公开/授权文献
- US20120027803A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS 公开/授权日：2012-02-02
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