发明授权
US09018234B2 Fluoro-substituted 2-aryl-3,5-dicyano-4-indazolyl-6-methyl-1,4-dihydropyridines and uses thereof
有权
氟取代的2-芳基-3,5-二氰基-4-吲唑基-6-甲基-1,4-二氢吡啶及其用途
- 专利标题： Fluoro-substituted 2-aryl-3,5-dicyano-4-indazolyl-6-methyl-1,4-dihydropyridines and uses thereof
- 专利标题（中）： 氟取代的2-芳基-3,5-二氰基-4-吲唑基-6-甲基-1,4-二氢吡啶及其用途
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申请号： US13509047申请日： 2010-11-08
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公开(公告)号： US09018234B2公开(公告)日： 2015-04-28
- 发明人: Alexandros Vakalopoulos , Martin Michels , Katja Zimmermann , Nicole Teusch , Mario Lobell , Karen Engel
- 申请人： Alexandros Vakalopoulos , Martin Michels , Katja Zimmermann , Nicole Teusch , Mario Lobell , Karen Engel
- 申请人地址： DE Monheim
- 专利权人： Bayer Intellectual Property GmbH
- 当前专利权人： Bayer Intellectual Property GmbH
- 当前专利权人地址： DE Monheim
- 优先权： EP09175642 20091111
- 国际申请： PCT/EP2010/066983 WO 20101108
- 国际公布： WO2011/069761 WO 20110616
- 主分类号： A01N43/40
- IPC分类号： A01N43/40 ; A61K31/44 ; C07D211/02 ; C07D401/00 ; C07D413/14 ; C07D401/04 ; C07D401/14
摘要：
The present invention relates to novel, fluoro-substituted 2-aryl-3,5-dicyano-4-(1H-indazol-5-yl)-6-methyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly Cancer and other proliferative disorders.
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