- 专利标题: Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
-
申请号: US13136897申请日: 2011-08-12
-
公开(公告)号: US09023605B2公开(公告)日: 2015-05-05
- 发明人: Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
- 申请人: Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
- 申请人地址: US CA Santa Monica
- 专利权人: Agensys, Inc.
- 当前专利权人: Agensys, Inc.
- 当前专利权人地址: US CA Santa Monica
- 代理机构: Morrison & Foerster LLP
- 主分类号: G01N33/574
- IPC分类号: G01N33/574 ; C07K16/40 ; A61K39/395 ; A61K45/06 ; A61K47/48 ; A61K51/10 ; C07K16/30 ; G01N33/68 ; A61K39/00
摘要:
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.