发明授权
US09023890B2 Nitrate esters and their use for the treatment of muscle and muscle related diseases
有权
硝酸酯及其用于治疗肌肉和肌肉相关疾病的用途
- 专利标题： Nitrate esters and their use for the treatment of muscle and muscle related diseases
- 专利标题（中）： 硝酸酯及其用于治疗肌肉和肌肉相关疾病的用途
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申请号： US12629230申请日： 2009-12-02
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公开(公告)号： US09023890B2公开(公告)日： 2015-05-05
- 发明人: Guqi Wang , Qi Long Lu
- 申请人： Guqi Wang , Qi Long Lu
- 申请人地址： US NC Charlotte
- 专利权人： The Charlotte-Mecklenburg Hospital Authority
- 当前专利权人： The Charlotte-Mecklenburg Hospital Authority
- 当前专利权人地址： US NC Charlotte
- 代理机构： Alston & Bird LLP
- 主分类号： A61K31/21
- IPC分类号： A61K31/21 ; C07C203/08 ; A61K31/27 ; A61K45/06 ; C07C203/04
摘要：
Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H; R2 is ONO2, CH2ONO2, Cn′H2n′+1OH, Cn′H2n′+1OH, CH2CH2CH3 or H; and R3 is ONO2, CH2ONO2, Cn′″H2n″+1OH, Cn″H2n″+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n′ is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n′+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.
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