发明授权
- 专利标题: Benzonaphthyridinamines as autotaxin inhibitors
- 专利标题(中): 苯并吡啶胺作为自体吸收素抑制剂
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申请号: US13637161申请日: 2011-02-28
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公开(公告)号: US09029387B2公开(公告)日: 2015-05-12
- 发明人: Wolfgang Staehle , Melanie Schultz , Kai Schiemann
- 申请人: Wolfgang Staehle , Melanie Schultz , Kai Schiemann
- 申请人地址: DE Darmstadt
- 专利权人: Merck Patent GmbH
- 当前专利权人: Merck Patent GmbH
- 当前专利权人地址: DE Darmstadt
- 代理机构: Millen, White, Zelano & Branigan, P.C.
- 优先权: EP10003282 20100326
- 国际申请: PCT/EP2011/000964 WO 20110228
- 国际公布: WO2011/116867 WO 20110929
- 主分类号: A01N43/42
- IPC分类号: A01N43/42 ; A61K31/44 ; A61K31/497 ; A61K31/535 ; C07D471/00 ; C07D491/00 ; C07D498/00 ; C07D513/00 ; C07D515/00 ; C07D401/00 ; C07D413/00 ; C07D471/04
摘要:
The present invention relates to benzonaphthyridinamines of the formula (I) as autotaxin inhibitors and to the use thereof in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in which the inhibition, regulation and/or modulation of phosphodiesterase or lysophospholipase autotaxin plays a role, in particular of various types of cancer and autoimmune and inflammatory diseases.
公开/授权文献
- US20130012505A1 BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS 公开/授权日:2013-01-10