- 专利标题: Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
-
申请号: US13199539申请日: 2011-08-31
-
公开(公告)号: US09029516B2公开(公告)日: 2015-05-12
- 发明人: Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
- 申请人: Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
- 申请人地址: US CA Santa Monica
- 专利权人: Agensys, Inc.
- 当前专利权人: Agensys, Inc.
- 当前专利权人地址: US CA Santa Monica
- 代理机构: Arnold & Porter LLP
- 代理商 Jessica Richardson; Gabor Brasnjo
- 主分类号: C07K14/00
- IPC分类号: C07K14/00 ; C07K14/47 ; A01K67/027 ; A61K51/10 ; C07K14/705 ; C07K14/72 ; C07K16/30 ; C12N9/02 ; G01N33/574 ; A61K38/00 ; A61K39/00
摘要:
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.