发明授权
- 专利标题: Nitrogen-containing condensed heterocyclic compound
- 专利标题(中): 含氮稠合杂环化合物
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申请号: US14004950申请日: 2012-03-14
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公开(公告)号: US09035059B2公开(公告)日: 2015-05-19
- 发明人: Tsuyoshi Busujima , Takahiro Oi , Hiroaki Tanaka , Yoshihisa Shirasaki , Kanako Iwakiri , Nagaaki Sato , Shigeru Tokita
- 申请人: Tsuyoshi Busujima , Takahiro Oi , Hiroaki Tanaka , Yoshihisa Shirasaki , Kanako Iwakiri , Nagaaki Sato , Shigeru Tokita
- 申请人地址: JP Tokyo
- 专利权人: TAISHO PHARMACEUTICAL CO., LTD.
- 当前专利权人: TAISHO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Tokyo
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2011-056015 20110314
- 国际申请: PCT/JP2012/056600 WO 20120314
- 国际公布: WO2012/124744 WO 20120920
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D209/44 ; C07D217/04 ; C07D223/16 ; C07D405/12 ; C07D409/06 ; C07D413/06 ; C07D417/10 ; A61K31/4035 ; A61K31/454 ; A61K31/472 ; A61K31/497 ; C07D217/18 ; C07D217/06 ; C07D217/22 ; C07D401/06 ; C07D401/10 ; C07D401/12 ; C07D403/12 ; C07D405/06 ; C07D413/12 ; C07D417/06 ; A61K9/16 ; A61K9/20 ; A61K9/48 ; C07D217/20 ; C07D217/26 ; C07D405/14 ; C07D409/14 ; C07D417/12 ; C07D417/14 ; C07D495/04 ; C07D217/10 ; C07D401/08
摘要:
There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group, RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula —CR11R12—, —CO—, —CO—O—, or —CO—NH—, W represents a single bond or a C1-3 alkylene group, and Ring B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group, Y represents a nitrogen atom or the formula N+(RF), RF represents a C1-4 alkyl group, and m and n, which may be the same or different, each represent an integer of 0 or 1.
公开/授权文献
- US20140005382A1 NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND 公开/授权日:2014-01-02
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