Invention Grant
- Patent Title: Veterinary formulation for administration of a water-insoluble drug to a target animal through a water distribution system
- Patent Title (中): 用于通过配水系统向目标动物施用水不溶性药物的兽用制剂
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Application No.: US12259844Application Date: 2008-10-28
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Publication No.: US09040571B2Publication Date: 2015-05-26
- Inventor: Peter Frank Ekhart , Mario Van Wandelen , Jan Matthijs Jetten
- Applicant: Peter Frank Ekhart , Mario Van Wandelen , Jan Matthijs Jetten
- Applicant Address: IE Sligo
- Assignee: Elanco Animal Health Ireland Limited
- Current Assignee: Elanco Animal Health Ireland Limited
- Current Assignee Address: IE Sligo
- Agent James J. Sales; Elizabeth A. McGraw
- Priority: EP99202876 19990903
- Main IPC: A01N43/52
- IPC: A01N43/52 ; A61K31/415 ; A61K9/107 ; A61K47/36 ; A61K47/44

Abstract:
This invention concerns a method for the preparation of a suspoemulsion formulation, which can be easily produced on an industrial scale and which allows the reproducible and effective administration of one or more water-insoluble veterinary drugs through water distribution systems. The water-insoluble veterinary drug, in finely ground form, is dispersed in a water immiscible liquid, followed by homogenization of this system into a water phase. To facilitate the preparation of a stable formulation, one or more stabilizing agents such as emulsifiers, thickeners, anti-oxidants and anti-microbials can be used. The resulting suspoemulsion shows excellent long term storage stability and a good “in use” stability after dilution in a vessel and during all handling and transport in the water distribution system.
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