The present invention provides two methods for configuring transmit power of sounding reference signal (SRS), a network device and a UE. One of the methods includes: with a network device, determining SRS transmit power parameters according to power level of signal previously sent from a UE received by each cell to be detected and/or information of cells to be detected by the UE, and sending the SRS transmit power parameters to the UE. The present invention can have an overall consideration on path losses of multiple cells to be detected when calculating the SRS transmit power. Therefore, the power of the cell having poor channel quality for receiving SRS can be guaranteed, in order to ensure the accuracy of channel estimation.