Two or more virtual machines may be co-located on a same physical machine, and the virtual machines may communicate with each other. To establish efficient communication, memory mapping information for respective virtual machines can be exchanged between the respective virtual machines. An instance of a virtualized network interface can be established, and a direct communications channel can be mapped between respective virtualized network interfaces. Data packet routing information can be updated, such that data packets transferred between two of more co-located virtual machines can be transferred using the virtualized network interface communications channel.