Embodiments of the present invention address deficiencies of the art in respect to configuring a computing appliance and provide a method, system and computer program product for device certificate based virtual appliance configuration. In one embodiment of the invention, a virtual appliance secure configuration method can be provided. The method can include mounting non-volatile storage to the virtual appliance, retrieving a device certificate from the mounted storage and extracting a signature from the device certificate, activating the virtual appliance in a network domain and acquiring an adapter address and unique identifier for the virtual appliance, and authenticating the signature with the adapter address and unique identifier to ensure a unique active instance of the virtual appliance.